CO₂ Laser While on Accutane - Why Timing Still Matters

In aesthetic medicine, some of the hardest decisions aren’t about what can be done - but what should be done.

Recently, I saw a 19-year-old male with fair (Fitzpatrick I) skin who had been under a private Dermatologist for acne. His condition was well-controlled on isotretinoin (Accutane), with no active breakouts - only a few mild rolling scars across the cheeks.

Traditionally, the teaching has been to avoid ablative (even fractional) lasers for at least 6–12 months after stopping isotretinoin, due to the risk of delayed healing and abnormal scarring. It’s a guideline I’ve always respected, especially since I had never personally treated anyone still on active Accutane.

The Request

He came in asking for CO₂ laser treatment for his acne scars. According to him, his Dermatologist had “given the go-ahead” - citing a JAMA paper suggesting that limited fractional treatments could be safe even during isotretinoin use.

I was puzzled. If so, why not continue the treatment there? He was upfront about practical considerations, and said he valued my support in helping him get ready for university next year. It was a relatable, human reason and it deserved a thoughtful discussion, not a blanket “no.”

The Discussion

We went through everything in detail:

1. My own experience - I told him clearly that I had never performed CO₂ resurfacing on a patient currently taking isotretinoin.

2. Expectations - One session alone rarely changes much; meaningful improvement often takes two to three sessions, sometimes more.

3. Technical differences - Every machine behaves differently, even within the same category of fractional CO₂ lasers, so comparing outcomes between clinics isn’t straightforward should he seek further treatment elsewhere.

4. Consent - At 19, parental consent is still required in Singapore, especially for aesthetic treatments.

5. Skin type - Fitzpatrick I skin in the Singapore climate carries a higher risk of post-inflammatory pigmentation, even with cautious settings.

Proceeding - Carefully

After detailed counselling, and with parental consent, we agreed to proceed using customised low-energy settings to balance efficacy and safety. Treatment was uneventful, but the key wasn’t the laser - it was the process: how every decision, from pulse density to downtime expectations, was guided by judgment, not just guidelines.

Reflection

It’s easy to fire the laser. What takes real experience is knowing when not to, or how far to push safely. Literature evolves, and so does technology - but clinical judgment remains irreplaceable.

For this patient, it wasn’t just about chasing a perfect result. It was about understanding risk, trust, and timing - the three things that ultimately determine whether “safe enough” truly is.

Written by Dr Ng Zhi Yang, Singapore Plastic Surgeon, and Founder & Medical Director of Doctor Stitch, a specialist-led cosmetic surgery aftercare service.